Yes, I recently had to compile some stuff on Windows (I'm on an AMD Linux host) and VirtualBox just wouldn't start Microsoft's Windows dev VM (the one they provide for free for Virtualbox). I ended up learning how to use qemu and it works great...and as a bonus I was able to run a hackintosh (via https://github.com/kholia/OSX-KVM) and it works near flawlessly, which was something I was never able to accomplish with Virtualbox (granted I haven't tried in a few years).
I'm pretty happy with Qemu now, even if it's jsut a CLI interface. I was tempted to try the virt-* stuff, but honestly it seems like one more thing to learn so I'm going to hold off until I need something like copy/paste between VMs and can't figure it out in qemu direct.
Webcam, USB drives, Hardware Video Acceleration, all working without issue (after a pretty tough learning curve getting it set up).