The TL is terrifying when there's no one else around except some ne'er-do-wells. Anything goes in that situation. Where it's busy it's usually just unpleasant, running the Tenderloin gauntlet of a million aromas (the more belligerent cousin of the Mission gauntlet of a thousand aromas).

During the day time I'd be more concerned about stepping in human excrement or rivers of piss. In fact, walking to the BART tonight from the Tenderloin I dodged 3 piles of human shit and near-missed another.

The Tenderloin and Twitterloin are blights on this fair city, and its toxic presence is oppressively pervasive if you spend any amount of time downtown (or even further out, like Hayes Valley and the Castro). It's a startling example of complete public policy failure at all levels of government.